diff --git a/mod_wsgi-4.7.1-remove-rpath.patch b/mod_wsgi-4.7.1-remove-rpath.patch
new file mode 100644
index 0000000000000000000000000000000000000000..39963825209650fc1ebf5dc06be7883632a292ab
--- /dev/null
+++ b/mod_wsgi-4.7.1-remove-rpath.patch
@@ -0,0 +1,20 @@
+diff --git a/setup.py b/setup.py
+index bf272ba..824957d 100644
+--- a/setup.py
++++ b/setup.py
+@@ -465,15 +465,6 @@ EXTRA_COMPILE_FLAGS = (EXTRA_INCLUDES + CPPFLAGS + EXTRA_CPPFLAGS +
+         CFLAGS + EXTRA_CFLAGS + APR_INCLUDES + APU_INCLUDES)
+ EXTRA_LINK_ARGS = PYTHON_LDFLAGS + PYTHON_LDLIBS
+ 
+-# Force adding of LD_RUN_PATH for platforms that may need it.
+-
+-if os.name != 'nt':
+-    LD_RUN_PATH = os.environ.get('LD_RUN_PATH', '')
+-    LD_RUN_PATH += ':%s:%s' % (PYTHON_LIBDIR, PYTHON_CFGDIR)
+-    LD_RUN_PATH = LD_RUN_PATH.lstrip(':')
+-
+-    os.environ['LD_RUN_PATH'] = LD_RUN_PATH
+-
+ # On MacOS X, recent versions of Apple's Apache do not support compiling
+ # Apache modules with a target older than 10.8. This is because it
+ # screws up Apache APR % formats for apr_time_t, which breaks daemon
diff --git a/mod_wsgi.spec b/mod_wsgi.spec
index 3ccb66833e70ce8d8c9fd1351f1a10187e0ad3f7..ed95182b526b4961dd5b32a1e697d6ea0fe824fd 100644
--- a/mod_wsgi.spec
+++ b/mod_wsgi.spec
@@ -23,7 +23,7 @@
 
 Name:           mod_wsgi
 Version:        4.6.8
-Release:        4%{?dist}
+Release:        5%{?dist}
 Summary:        A WSGI interface for Python web applications in Apache
 License:        ASL 2.0
 URL:            https://modwsgi.readthedocs.io/
@@ -32,6 +32,7 @@ Source1:        wsgi.conf
 Source2:        wsgi-python3.conf
 Patch1:         mod_wsgi-4.5.20-exports.patch
 Patch2:         mod_wsgi-4.9.1-request-limit.patch
+Patch3:         mod_wsgi-4.7.1-remove-rpath.patch
 
 # Exclude i686 arch. Due to a modularity issue it's being added to the
 # x86_64 compose of CRB, but we don't want to ship it at all.
@@ -182,6 +183,10 @@ ln -s %{_bindir}/mod_wsgi-express-2 $RPM_BUILD_ROOT%{_bindir}/mod_wsgi-express
 %endif
 
 %changelog
+* Thu Jul 13 2023 Charalampos Stratakis <cstratak@redhat.com> - 4.6.8-5
+- Remove rpath
+Resolves: rhbz#2213836
+
 * Thu Sep 08 2022 Lumír Balhar <lbalhar@redhat.com> - 4.6.8-4
 - Core dumped upon file upload >= 1GB
 Resolves: rhbz#2125171